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marvin View Drop Down
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    Posted: 03 Nov 2011 at 11:10am
Hi
 
Could you point me to some references on prions? Heat etc.
 
Marve 
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michael View Drop Down
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Joined: 01 Sep 2009
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Points: 196 		Post Options Post Options   Thanks (0) Thanks(0)   Quote michael Quote  Post ReplyReply Direct Link To This Post Posted: 04 Nov 2011 at 9:10pm
Marvin
 
 I am recommending two references to get you started:

1. Blanchfield, J.R. 1998. Bovine spongiform encephalopathy (BSE)—a review. Int. J. Food Sd. Technol. 33:81-97.
2. Thomas Raul Appel, Michael Wolff, Friedrich von Rheinbaben, Michael Heinzeland Detlev Riesner. (2001) Journal of General Virology.  82, 465-473.
 
The latter reference provides a good overview of the heat resistance of 'prions' (there are different types) and also makes reference to the regulatory requirements within the EU e.g. autoclaving at 133 °C for 20 min for a prion inactivation factor  of 108.
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